Top Stock Movers – February 23, 2026
U.S. stocks closed sharply lower Monday after renewed tariff uncertainty rattled global markets, triggering broad selling across technology, financial, and consumer shares.The Dow Jones Industrial Average plunged more than 820 points, while the S&P 500 fell 1% and the Nasdaq dropped 1.1%, reversing gains from last week’s rally.Despite the widespread weakness, a handful of stocks posted outsized moves.
📈 Top Gainers
Arcellx (ACLX) +77%
Arcellx shares skyrocketed after the biotech firm agreed to be acquired by Gilead Sciences (GILD) for $115 per share in cash plus a contingent value right, valuing the deal at approximately $7.8 billion. The surge made Arcellx the day’s biggest standout performer.
Eli Lilly (LLY) +5%
Eli Lilly climbed after disappointing trial results from rival Novo Nordisk (NVO) strengthened its competitive position in the high-growth obesity drug market.
Domino's Pizza (DPZ) +4%
Domino’s rose after reporting better-than-expected quarterly revenue and same-store sales, while also announcing a 15% dividend increase.
📉 Top Losers
Novo Nordisk (NVO) -16%
Novo Nordisk tumbled to its lowest level in nearly five years after its experimental obesity drug CagriSema delivered weaker-than-expected weight-loss results, intensifying competitive pressures.
IBM (IBM) -13%
IBM sank on concerns that rapid advances in artificial intelligence technology could weigh on its enterprise software and AI positioning.
Software & Cybersecurity Stocks Slide
High-growth tech names were broadly under pressure:
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Datadog (DDOG) down 11%
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CrowdStrike (CRWD) down 10%
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AppLovin (APP) down 9%
The declines reflect a rotation out of high-multiple AI names as investors grow cautious about elevated valuations and the durability of AI-driven momentum.
Airline Stocks Hit by Blizzard
Airline shares also dropped sharply after thousands of flight cancellations across the Northeast:
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Delta Air Lines (DAL) down 3.8%
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United Airlines (UAL) down 5%
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American Airlines (AAL) down 5.2%
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